期刊名称：Lecture Notes in Engineering and Computer Science
印刷版ISSN：2078-0958
电子版ISSN：2078-0966
出版年度：2018
卷号：2233&2234
页码：731-736
出版社：Newswood and International Association of Engineers
摘要：The overall objective of this research is to design,
develop, and evaluate an onboard high-performance Positron
Emission Tomography (PET) that will be integrated into an
existing CT image-guided small animal precision X-ray
radiation therapy system (CT/RT). This new PET/CT/RT will
enable streamlined PET/CT biology functional and organ
anatomic dual-modality images to guide the therapy, and
provide substantially improved beam targeting accuracy and
therapy response evaluation. Both simulation and experiment
studies were conducted to investigate the detector design with
different resolutions, sensitivities, readout methods, and PET
system configurations with different image field of view (FOV)
and image performance tradeoffs. The results have shown that
the 1.0 mm PET uniform image resolution and ~4% system
sensitivity can be achieved within a 80 mm trans-axial and 30
mm axial image FOV. A prototype detector that has been
developed and evaluated can achieve energy, coincidence
timing, and depth-of-interaction resolutions at ~16%, 1.14 ns,
and <3.0 mm respectively. In summary, the overall PET
detector and system design studies have been successfully
conducted for establishing solid technical solutions to develop
the PET/CT/RT system.
