摘要：LC/Tribrid Orbitrap was developed to determine phosphodiesterase-5 （PDE-5） inhibitors and
their analogs as adulterants in dietary supplements. High-resolution MS/MS and MS3
spectra of
PDE-5 inhibitors and their analogs were obtained by LC/Tribrid Orbitrap using both higher-energy
collisional dissociation and collision-induced dissociation. We investigated dietary supplements that
claim to enhance men’s sexual performance, and detected PDE-5 inhibitors and their analogs. We
also estimated the structures of the PDE-5 inhibitor analogs and the impurities of PDE-5 inhibitors
and their analogs in the dietary supplements.
