首页    期刊浏览 2024年12月26日 星期四
登录注册

文章基本信息

  • 标题:UV light suppression of EAE (a mouse model of multiple sclerosis) is independent of vitamin D and its receptor
  • 本地全文:下载
  • 作者:Amy A. Irving ; Steven J. Marling ; Jeremy Seeman
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2019
  • 卷号:116
  • 期号:45
  • 页码:22552-22555
  • DOI:10.1073/pnas.1913294116
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Vitamin D and sunlight have each been reported to protect against the development of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). To date, the contribution of each has been unclear as ultra violet (UV) exposure also causes the generation of vitamin D in the skin. To examine whether the UV based suppression of EAE results, at least, in part from the production of vitamin D, we studied the effect of UV light on EAE in mice unable to produce 7-dehydroxycholesterol (7-DHC), the required precursor of vitamin D. Furthermore, we examined UV suppression of EAE in mice devoid of the vitamin D receptor (VDR). Our results demonstrate that UV light suppression of EAE occurs in the absence of vitamin D production and in the absence of VDR. Future investigations will focus on identifying the pathway responsible for the protective action of UV in EAE and presumably human MS..
  • 关键词:UV light ; vitamin D receptor ; experimental autoimmune encephalomyelitis
国家哲学社会科学文献中心版权所有