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  • 标题:A consideration of within-host human cytomegalovirus genetic variation
  • 本地全文:下载
  • 作者:Jeffrey D. Jensen ; Timothy F. Kowalik
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2020
  • 卷号:117
  • 期号:2
  • 页码:816-817
  • DOI:10.1073/pnas.1915295117
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:In Cudini et al. (1), the authors suggest that earlier work has argued high levels of intrahost variation in human cytomegalovirus (HCMV) to be the result of exceptionally fast mutation rates (on par with RNA viruses), citing our recent review (2) as evidence. In reality, ref. 2 noted that levels of variation can be comparable to those observed in certain RNA viruses (as Cudini et al. reconfirm), and that this required explanation “in light of the low mutation rates of herpesviruses relative to those of RNA viruses.” In the summarized primary literature, ref. 3 argued that fast mutation rates could explain … [↵][1]1To whom correspondence may be addressed.
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