This paper proposes a degree-of-priority based control strategy for emergency vehicle preemption operation to decrease the impacts of emergency vehicles on normal traffic. The proposed model features its effectiveness to the following three aspects: (1) a multilayer fuzzy model was established to determine the degree-of-priority based on emergency vehicle preemption demand intensity and preemption influence intensity; (2) for emergency vehicles with proper classification, a travel time estimation model for emergency traffic was formulated, an optimal emergency route determines model based on the level of priority of emergency events, and the emergency vehicle travel time was developed to minimize evacuation time as well as minimize the adverse impacts of preemption on normal traffic; and (3) a conditional traffic signals priority control method at each intersection of the evacuation route was built, so that traffic queue at each intersection can be cleared before the arrival of emergency vehicles. A simulation model based on field data was developed, and the performance of the proposed strategy was compared with the conventional local detection based method under the microscopic simulation model. The results validated the efficiency of the proposed strategy in terms of minimizing the delay of emergency vehicles and reducing adverse impacts on normal traffic.