摘要:Introduction and Aim .Substance abuse imposes hazards on human health in all biopsychosocial aspects.Limited studies exist on epidemiology of substance abuse and its trend in rural areas.The present study aimed to compare substance abuse in one of the rural areas of southeast Iran, in a 12-year period (2000 and 2012).Design and Methods .In a household survey conducted in 2012, in Dashtkhak/Kerman, 1200 individuals above 12 years of age completed a questionnaire to determine their frequency of substance abuse.The questionnaire included the following three areas: demographic characteristics, frequency of substance abuse and ease of access to various drugs.Results .Among 900 completed questionnaires, majority of the participants (61.8%) were below 30 years of age and among them 54.4% were male.Cigarette (17.0%), opium (15.7%) and opium residue (9.0%) were the most frequent substances abused on a daily basis.Based on the participant’s opinion, we conclude that the ease of access to cigarette, waterpipe and opium contributed to their increase in consumption compared with earlier years.Discussion and Conclusion .The steady rise in substance abuse in rural communities demands immediate attention and emergency preventive measures from policy makers.