摘要：Background: Freezing all embryos generated during an IVF/ICSI attempt is used increasingly as a strategy to
optimize results. We investigated whether we could fnd differences in outcome between subpopulations of patients
undergoing the so-called “freeze all” procedure.
Methods: Non-interventional, observational, retrospective study of 131 freeze-all cycles performed between July
2015 and December 2016 at the University Hospital of Ghent (Belgium). Freeze-all indications were categorized
in 4 groups: group 1, high progesterone level (PE) on the day of hCG administration defned as >1.5 ng/ml (n=
50); group 2, risk of Ovarian Hyperstimulation Syndrome (OHSS) (n=38); group 3, partner donation in lesbian
couples (n=23) and group 4, a miscellany of other reasons (n=20). Clinical pregnancy with fetal heart beat after the
frst thawed embryo transfer (ET) after ovum pick-up and cumulative clinical pregnancy rate per attempt were
used as primary outcome variables.
Results: Clinical pregnancy rate (CPR) with fetal heart beat in the frst thawed ET and cumulative clinical
pregnancy rate per cycle (CCPR) were not statistically different between the four groups. In the group of PE a
cumulative clinical pregnancy rate was observed of 40,5%, this in comparison to the 3 other groups involving risk
of OHSS (66,7%), partner donation (61,1%) and other reasons (57,1%). More rFSH was used in the group with
Progesterone elevation (PE) (P=0.04), as described earlier in the literature.
Conclusion: Our fndings indicate comparable (cumulative) clinical pregnancy rates per attempt between the four
groups of freeze-all indications.
