摘要：Introduction: Adenomyosis often co-exists in the pathological specimens after surgery for endometrial cancer. The
aim of this study is to describe the clinicopathological and oncological characteristics of these patients and further
investigate the possibility of malignant transformation in the adenomyotic tissue.
Methods: We retrospectively reviewed the medical records of all patients that underwent hysterectomy for
endometrial cancer (January 2012 – December 2017). The pathological reports were studied and when adenomyosis
was present, the pathological slides were reviewed in order to discover any malignant change in the adenomyotic
tissue. The clinicopathological characteristics and oncological results were described.
Results: Out of 229 cases of endometrial cancer, 64 (28%) patients had concurrently endometrial cancer and
adenomyosis. Among these 64 patients, 7 (11%) had malignant transformation of adenomyosis. The mean age
of patients suffering from both endometrial cancer and adenomyosis was 63.2 years old and 57 (89%) of these
patients, had early endometrial cancer. Concerning the patients with malignant transformation of adenomyosis,
their mean age was 65 years old with no premenopausal case.
Discussion: Adenomyosis has been described in the last decades, but its malignant transformation into endometrial
cancer is not fully undercovered. Further investigation is needed in order to clarify the pathologic progression of
adenomyotic lesions to endometrial cancer.
