摘要：Background and Study Aim: I/D polymorphism of the ACE gene is one of the best known genetic variants which affects physical performance
in humans. Another variant of genes which can play an important role in predisposition to sport engagement
are Arg16Gly and Gln27Glu of the ADRB2 gene and K153R of the MSTN gene. ADRB2 is expressed
on bronchial smooth muscle and is associated with lipid metabolism. These genotypes influence the RAS function,
affecting the body’s water and sodium balances. In turn, MSTN modulates myoblast proliferation and
hence muscle mass and strength. This study aimed to answer the question of whether selected gene variants
(I/D, Arg16Gly, Gln27Glu, and K153R polymorphisms in the ACE, ADRB2, and MSTN genes, respectively) have
a relationship with achievements obtained by competitive judo athletes and their predisposition to injuries.
Material and Methods: In our study, 82 judo athletes from Poland and 26 from Croatia took part. We studied the contribution of selected
polymorphisms of ACE, ADRB2 and MSTN genes in judo practitioners. The study was conducted on
DNA isolated from buccal cells. The genotypes of the ACE, ADRB2 and MSTN genes were determined by ASAPCR
and RFLP-PCR.
Results: Genotypes ID and Arg16Gly were associated with better performances in competitions (most placed 2nd in
competition, p=0.06). Furthermore, the I allele may predispose an individual to joint injuries (OR=1.69, p=0.03)
while the Gln allele may protect an individual from spinal injuries (OR=0.58, p=0.054), respectively.
Conclusions: ACE and ADRB2 genes may also influence leg muscle strength and body weight in judo participants.
