摘要：Background and Study Aim: In sport, pain plays a pivotal but dual role which is still not fully understood and requires closer cooperation
between specialists in the fields of sports medicine, sports science and psychology. The aim of this study was
the knowledge about the possible association between rs6746030 (G/A substitution) genotype variants and
pain tolerance in boxers.
Material and Methods: Ninety-nine boxers completed the cold pressor test (CPT), a standard laboratory technique used to measure
pain tolerance and the pain threshold. Heart rate and blood pressure were measured at three-time points
during the CPT. Three hundred and thirty-two non-athletic subjects served as a control group.
Results: Chi-square test analysis showed no significant differences in genotype or allele frequencies between cases
and control subjects (p = 0.963 for both genotypes and alleles). Contrary to the results of other studies, the
SCN9A rs6746030 genotype did not affect phenotypic variables of pain.
Conclusions: Pain seems to be a complex trait. It is likely that several gene loci, each with a small but significant contribution,
are responsible for this genetic component. Further large, well-designed studies are necessary to determine
its genetic background.
