标题：SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II), COBALT(III) AND IRON(III) COORDINATION COMPOUNDS WITH 1-(2-HYDROXYPHENYL)ETHANONE N(4)-ALLYL-S-METHYLISOTHIOSEMICARBAZONE
期刊名称：Studia Universitatis Moldaviae: Stiinte Sociale
印刷版ISSN：1814-3199
电子版ISSN：2345-1017
出版年度：2018
卷号：1
期号：111
页码：144-150
出版社：Moldova State University
摘要：The paper presents the synthesis of the 1-(2-hydroxyphenyl)ethanone N(4)-allyl-S-methylisothiosemicarbazone
(HL) and seven coordination compounds of copper, nickel, cobalt and iron with this pro-ligand. The newly obtained
compounds were investigated by IR, 1H and 13C NMR spectroscopy, elemental analysis, molar electric conductibility
and magnetic susceptibility. For the synthesized compounds the antibacterial and antifungal activities in vitro were
studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922),
Klebsiella pneumonae and Candida albicans. The in vitro antiproliferative activity of the pro-ligand and complexes was
screened on Hep-2, BxPC-3, RD cancer cells and normal MDCK cells. It was established that coordination compounds
manifest better antiproliferative activity than the pro-ligand.
