期刊名称：Studia Universitatis Moldaviae: Stiinte Sociale
印刷版ISSN：1814-3199
电子版ISSN：2345-1017
出版年度：2018
卷号：6
期号：116
页码：70-76
出版社：Moldova State University
摘要：This study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-
[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells
of lines. It was established, that the copper(II) mixed-ligand complex exhibits the highest anticancer activity against
MeW-164, HeLa, BxPC-3 and RD cells of lines with IC50 values of 1.0±0.2, 0.4±0.04, 1.7±0.2, 1.3±0.3 µM,
respectively. A comparative study between the tested compound and DOXO in regard to cancer lines has established
that the tested copper(II) mixed-ligand complex exhibits stronger inhibitory activity on cancer cells proliferation than
doxorubicin and cisplatin.
关键词：mixed;ligand complex; doxorubicin; cisplatin; anticancer activity; cancer cells of line;
