标题：SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II), COBALT(III) AND IRON(III) COORDINATION COMPOUNDS WITH 2-HYDROXY-3-METHOXYBENZALDEHYDE N(4)-ALLYL-S-ETHYLISOTHIOSEMICARBAZONE
期刊名称：Studia Universitatis Moldaviae: Stiinte Sociale
印刷版ISSN：1814-3199
电子版ISSN：2345-1017
出版年度：2018
卷号：6
期号：116
页码：89-96
出版社：Moldova State University
摘要：The paper presents the synthesis of the 2-hydroxy-3-methoxybenzaldehyde N(4)-allyl-S-methylisothiosemicarbazone
(HL) and seven coordination compounds of copper, nickel, cobalt and iron with this ligand. The new obtained
compounds were studied using IR, 1H and 13C NMR spectroscopy, elemental analysis, molar electric conductibility and
magnetic susceptibility. The in vitro antiproliferative activity of the HL and synthesized coordination compounds was
screened on HeLa cancer cells and normal MDCK cells. The isothiosemicarbazone HL shows better anticancer activity
towards HeLa cancer cells than doxorubicin that is used in medical practice and it also practically does not affect the
growth and proliferation of normal cells. Moreover, it manifests high antioxidant activity towards ABTS•+ radical cation
that exceeds the activity of trolox.
关键词：coordination compounds; 2;hydroxy;3;methoxybenzaldehyde; isothiosemicarbazone; antitumor activity;
cancer cells; antioxidant activity;
