期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2018
卷号：7
期号：5
页码：5324-5329
DOI：10.15680/IJIRSET.2018.0705105
出版社：S&S Publications
摘要：To determine the effects of metal complexes Ni(II), Co(II) and Zn(II) have been synthesized with
Gliclazide that is (N-(hexahydrocyclopenta[C]-pyrrol-2(1H)-ylcarbamoyl-4-methylbenzene sulphonamide is a second
generation sulphonyl-urea drug. Gliclazide works in several different ways, but its primary function is to increase
insulin Sensitivity, improve glucose clearance and reduce the amount of hepatic glucose produced. Analytical data and
stochiometry suggest ligand metal ratio of 2:1 for Ni(II), Co(II) and Zn(II) complexes. The metal ligand behaves as a O
donor. Infrared spectral studies confirm the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached
from other side with the metal ion. From the magnetic data and IR spectra, on the basis of electronic spectral value the
complexes are proposed to have the geometrical structure of complex is octahedral Ni(II), Co(II) and tetrahedral
structure of Zn(II). The complex has been formulated as [Ni(C15H21N3O3S)2(H2O)2], [Co(C15H21N3O3S)2(H2O)2] and
[Zn(C15H21N3O3S)2] .
