标题：Analyze the status of 5?methylcytosine DNA methylation level in the CpG Island of promoter region of BDNF gene for the pathogenesis of Type II Diabetic Retinopathy
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2018
卷号：7
期号：8
页码：9179-9184
DOI：10.15680/IJIRSET.2018.0708048
出版社：S&S Publications
摘要：Type 2 Diabetic retinopathy (T2DR) is a sight threatening, microvascular complication of diabetes
thataffects the retina. It is the most common complication of diabetes and a leading cause of blindness amongst
working aged adults in the developed world.It is broadly recognized as a neurovascular disease. Patients suffering from
T2DR are one third of human population suffering from diabetes mellitus. Retina is a neuronal tissue of the eye
produces neurotrophic factors for its maintenance. Brain-derived neurotrophic factor (BDNF) is one of the neurotrophic
factors that support differentiation and maturation. BDNF helps retinal cell survival in a concentration dependent
Manner. BDNF may protect retina from hyperglycemia and provides pathogenesis of T2DR.DNA methyltransferases
(Dnmts) catalyses methylation of cytosine to 5-methyl cytosine (5mC).Dnmts a family with five different members—
Dnmt1, Dnmt2, Dnmt3a, Dnmt3b and Dnmt3L; out of which only Dnmt1 Dnmt3a and Dnmt3b are catalytically
active.It has been observed that level of BDNFdysregulates during the pathogenesis in T2DR patients.Present review
concluded that the level of 5’ methyl cytosine DNA methylation on BDNF in a retinal cell affects the microvasculature
of human retina that can named as neovascularization or any retinal microvasculopathy.The analysis of 5’methyl
cytosine DNA methylation on BDNF between the patient and a healthy person can be important in the establishment of
cause of T2DR and may provide hints about their unique role in the pathogenesis of disease.
关键词：Type 2 Diabetic Retinopathy; Epigenetic; DNA Methylation; Brain derived neurotrophic factor; DNA
methyltransferase;
