In the field of medical informatics, there has been a paradigm shift from the adoption of the conventional Picture Archiving and Communication System (PACS) to cloud-based PACS because of the cost-effectiveness and storage computational efficiency. However, cloud-plugged technologies are subject to security and network performance issues because of the internetworking and interoperability over the internet. Hence, this work focused on the development and evaluation of a secured cloud-based PACS framework so as to assess the usability of the technology in developing countries of the World through a case study approach.