One of the most important concerns of medical care is health care-associated infection. Certain bacterial species can be involved, but they produce different types of diseases. Clostridium difficile have been associated with intestinal diseases in humans, mostly after antibiotic treatments for a long period. These infections can vary from mild diarrhea to severe colitis. The aim of this paper was to establish the incidence of this kind of enteric infections in 2017-2018 in patients from Arges hospital. 294 patients were investigated, age one to 94 years, from villages and towns, both women and men. The most patients had age over 60 years. The presence of toxins was detected. The incidence of infections was higher in men than in women; mostly toxin B was detected in patients. The main attention in many infections is the ability of antibiotics to reduce both pathogenic and saprophytic bacteria, so the pathogens like Clostridium difficile can increase and cause enteric diseases.