期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：2
页码：1-5
DOI：10.26444/aaem/80708
出版社：Institute of Agricultural Medicine in Lublin
摘要：Hematologic disorders, including thrombocytopenia, are a common symptom of systemic lupus – Systemic Lupus
Erythematosus (SLE). An important diagnostic and therapeutic issue is the severe and recurrent thrombocytopenia resistant
to standard treatment. It requires extensive diagnostics and a multi-directional view on its causes beyond the autoimmune
process. Currently, there is no single treatment regimen for these disorders. Corticosteroids (CS) are the first-line drugs, but
their chronic use is a big problem, they are not always successful and often generate a number of complications, especially
in moderate to high doses. In the case of thrombocytopenia associated with the activity of SLE, immunosuppressive therapy
is the gold standard and may result in long-term remission of symptoms and clinical stabilization. The major problem is
thrombocytopenia resulting from other causes, such as infection or medications. This study discusses severe recurrent
thrombocytopenia on the basis of three clinical cases, analyzing both the various causes of disorders, and providing ways
of management and treatment. Special attention is paid to the correlation of thrombocytopenia with the clinical and
immunological activity of SLE. It seems that severe and refractory thrombocytopenia may be a critical point and largely
determine the management and treatment possibilities of SLE.
