期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：2
页码：1-5
DOI：10.26444/aaem/85929
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. To-date, the influence of heavy metals such as Pb or Cd on mental functioning, and especially on the
occurrence of depressive and anxiety-related disorders, has not been well understood.
Objectives. 1) Assessment of Pb and Cd levels in whole blood of postmenopausal women. 2) Assessment of the severity
of anxiety and depressive symptoms depending on Pb and Cd levels in whole blood of postmenopausal women.
Materials and method. The survey-based study involved 198 healthy postmenopausal women from West Pomeranian
province in Poland. It was performed using the Primary Care Evaluation of Mental Disorders (PRIME-MD), Beck’s Depression
Inventory (BDI), and the State-Trait Anxiety Inventory (STAI). The second part of the study was based on biochemical analysis
of the levels of heavy metals (Pb, Cd).
Results. The mean level of Pb was 19.85 ± 8.99 µg/l and Cd 0.87±0.98 µg/l; these levels were within normal ranges. Analysis of
the mean levels of Pb and Cd in whole blood of postmenopausal women in relation to the severity of depressive symptoms
did not reveal statistically significant differences. Correlation analysis demonstrated a statistically significant (p<0.05) negative
correlation (-0.22) between the level of Pb and the severity of anxiety as a state. Correlations between the levels of Pb and
Cd and the severity of anxiety as a trait were not statistically significant.
Conclusions. The mean Pb and Cd levels in whole blood of healthy postmenopausal women did not exceed acceptable
limits. The study did not confirm a relationship between the levels of selected heavy metals and the severity of anxiety
and depressive symptoms in healthy women. However, there was a relationship between the level of Pb and the severity
of anxiety as a state.
关键词：Pb; Cd; depressive disorder; anxiety; postmenopausal women
