期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：3
页码：1-3
DOI：10.26444/aaem/85652
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. Acromegaly is an endocrine disorder caused predominantly by pituitary adenoma leading to autonomic
oversecretion of growth hormone and secondary elevation of insulin-like growth factor 1 (IGF-1). Consequently, there are
both theoretical and experimental grounds for establishing a correlation between this disorder and the higher incidence
of neoplasms.
Objective. The aim of the study is to evaluate the incidence and types of neoplasms among patients with acromegaly.
Materials and method. The study included 67 patients with acromegaly, aged between 24 and 75±18.8 years, 46 women
(68.7%) and 21 men (31.3%), BMI: 30.7±5.7 kg/m2, age at diagnosis 49.1±12.5 years, with the medians of GH and IGF-1 levels
at diagnosis of 11.3 ng/ml and 663.8 ng/ml, respectively. A retrospective analysis of medical records with particular regard
to physical examination, medical history, laboratory and imaging tests was performed.
Results. Fifty-one patients (76.1%) suffered from at least one neoplasm, among whom 48 patients (71.6%) had benign
proliferations, whereas malignant neoplasms (larynx, endometrial and colon cancers) were found in only three patients
(4.5%).
Conclusions. Benign neoplasms were found in majority of patients with acromegaly (71.6%) most notably: nodular goiter
and colon polyps; malignant lesions were rare (4.5%). Only every fifth patient suffered from no neoplastic proliferations.
No correlations between the studied parameters and the incidence of neoplasms were found, most likely due to the small
number of patients. This is the reason for proposing the creating of the first national register of incidences of neoplasms
among acromegalic patients.
