期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：3
页码：1-5
DOI：10.26444/aaem/92650
出版社：Institute of Agricultural Medicine in Lublin
摘要：The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis
and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from
the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol
consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals
without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA
kits. The concentration of afamin was found to be significantly lower in patients with compensated alcoholic liver cirrhosis,
i.e. P-Ch B (85.1±40.6 μg/ml) and P-Ch C (56.4±32.3 μg/ml) individuals, compared to the control group (135.9±43.6 μg/ml);
p-value was <0.01 and <0.001, respectively. As far as adropin is concerned, a reverse relationship was demonstrated: the
highest concentration was found in patients with P-Ch C (11.7±5.7 ng/ml) cirrhosis. Furthermore, the above concentration
was significantly higher compared to patients with P-Ch A cirrhosis (7.2±2.8 ng/ml; p<0.05) and controls (7.5±2.6 ng/ml;
p<0.05). The concentration of afamin decreases with the severity of alcoholic liver cirrhosis, which most likely results from
impaired hepatic synthesis. Otherwise, the higher the stage of disease according to the Child-Pugh score, the higher the
concentration of adropin.
