期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：3
页码：1-5
DOI：10.26444/aaem/86336
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. A growing number of epidemiological studies suggest that paracetamol, which is commonly used in children,
may be a risk factor for asthma, allergic rhinitis, and atopic eczema.
Objective. The aim of this study was to determine and characterize the correlation between paracetamol use and asthma,
allergic rhinitis, and atopic eczema symptoms in the Polish population.
Materials and method. The study is part of the ECAP project involving the use of the ISAAC and ECRHS questionnaires.
Completed questionnaires of 18,617 subjects, including 10,011 (53.8%) females, were analyzed. Children aged 6–7 (n=4,510),
adolescents aged 13–14 (n=4,721), and adults aged 20–44 (n=9,386) constituted 24.2%, 25.4%, and 50.4% of respondents,
respectively. Study subjects lived in 8 major urban centres and one rural area. The frequency of paracetamol use during
the previous 12 months and symptoms of asthma, allergic rhinitis, and atopic eczema during that period were analyzed.
Results. The use of paracetamol was associated with a significant dose-dependent increase in the risk of asthma symptoms in
all evaluated age groups. This was demonstrated via odds ratios (OR) for developing asthma symptoms, including wheezing
or whistling in the chest in 6–7-year-olds and exercise-induced shortness of breath in 13–14-year-olds and adults, depending
on the frequency of paracetamol use in the previous 12 months, compared to no paracetamol intake during that period.
Conclusions. The use of paracetamol in the last 12 months was associated with a significant dose-dependent increase in
the risk of rhinitis and skin allergy symptoms, as demonstrated by the odds ratio. Therefore, frequent paracetamol use may
be a risk factor for symptoms of asthma, rhinitis, and skin allergy in the Polish population.
