期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：3
页码：1-4
DOI：10.26444/aaem/83413
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. The aim of the study was to evaluate the differences between asthma and COPD on the basis
of the prevalence and profile of IgE-dependent sensitization to inhaled allergens, and the blood serum levels of select Th1/
Th2 cytokines.
Materials and method. 103 patients with COPD (114 patients with asthma and 121 controls) were included in the study.
A skin prick test with common inhaled allergens was performed, and serum levels of IgE were measured in all subjects.
Lymphocyte profiles were measured via the whole-blood method using fresh 10-ml blood samples treated with EDTA. The
following surface antigens were measured: CD3, CD29, CD16, CD56, CD4, CD8, and HLA-DR. The Th1/Th2 profile in blood
serum was determined using Th1/Th2 cytokine kits.
Results. IgE-dependent sensitization to environmental allergens was found in 34 (33.3%) patients with COPD, 46 (40%)
patients with asthma and in 14 (11.5%) volunteers. The odds ratio of sensitization in patients with COPD reached 0.89 (95%
CI: 0.57–1.08) and it was more frequent than in the control population with an odds ratio of 0.71 (95% CI: 0.64–0.88). The
serum concentration of IL-2 was significantly higher in patients with COPD and asthma than in controls. In the subgroup
of patients with non-allergic asthma, similar serum concentrations were observed for all analyzed cytokines, except for
IFN-gamma, which was lower in patients with COPD.
Conclusions. Both the prevalence and profile of IgE-dependent sensitization to inhaled allergens did not differ between
asthma and COPD. Both Th2 and Th1 played a role in the immunopathology of asthma and COPD.
