期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：4
页码：1-6
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Systemic sclerosis [SSc; scleroderma] is a rare, connective tissue disorder affecting all organs
and systems. The primary feature of this disease is a chronic, progressive fibrosis due to excessive production of collagen
and other components. There are two subsets of systemic sclerosis: 1) diffused SSc (dSSc), 2) limited SSc (lSSc) and 3)
scleroderma without sclerosis (SSSC). The presented review is an attempt to summarize recent data regarding environmental
and occupational factors in SSc onset.
State of knowledge. There are many factors to be taken under consideration with SSc onset, although a strong correlation
has been established for only a few. The most distinct factors are: crystalline silica and organic solvents (such as white
spirit, aromatic, aliphatic-chain, chlorinated solvents, ketones, welding fumes). For other factors, which include abstestos,
air pollution, other chemicals, silicone breast implants, tobacco smoking, drug reactions, diet influence and exposure to
heavy metals, the jury is still out, and their position in SSc onset needs further studies.
Conclusions. Although the pathogenesis of scleroderma remains unclear, there is a marked correlation between the onset
of SSc and certain environmental or occupational factors.
