期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：4
页码：1-6
DOI：10.26444/aaem/75802
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Data on the possible role of peritoneal fluid free radical-mediated oxidative damage in the
pathogenesis of endometriosis still remains inconsistent. The aim of the study was to determine iron metabolism markers
and their influence on oxidative stress parameters in the peritoneal fluid of women with endometriosis.
Materials and method. 110 women with endometriosis and 119 patients with benign ovarian cysts were included in the
study. All visible peritoneal fluid was aspirated during laparoscopy from the anterior and posterior cul-de-sacs. under direct
vision to avoid blood contamination. Haemoglobin, iron, total oxidative status, and total antioxidant status were measured
using standard colourimetric kits.
Results. Haemoglobin, iron levels, as well as total oxidative status values were significantly higher, whereas total antioxidant
status values were significantly lower in the peritoneal fluid of patients with endometriosis, in comparison to the reference
groups. No differences were observed in peritoneal fluid concentrations of all parameters measured in relation to the phase
of the menstrual cycle.
Conclusions. Peritoneal fluid of women with endometriosis is characterized by disrupted iron metabolism. This is most
likely related to an increased number of erythrocytes in the peritoneal cavity of endometriotic women, which leads to a
higher concentration of haemoglobin in this environment. Impaired iron homeostasis may have a significant influence on
the pathophysiology of peritoneal endometriosis by the direct impact of haemoglobin derivatives and/or formation of
the pro-inflammatory and pro-oxidative environment. Peritoneal cavity oxidative stress occurs predominantly in women
in advanced stages of the disease.
关键词：Endometriosis; peritoneal fluid; oxidative stress; haemaglobin; iron; total oxidative status; total antioxidant status
