期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2019
卷号：26
期号：1
页码：1-6
DOI：10.26444/aaem/92277
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Osteoarthrits (OA) is a complex, chronic disorder of cartilage and bone, related to homeostasis
of bioelements. The current study aimed at evaluation of correlations between plasma silicon, magnesium and ionized
calcium in OA patients in consideration to gender.
Materials and method. The study comprised 59 patients aged 69.5±9.0 years (18 males aged 66.8±9.2; 41 females aged
70.7±8.8), admitted to the Trauma and Orthopaedic Ward of the Independent Public Health Care Centre in Łęczna, Poland,
due to OA and qualified to surgery. Control group consisted of 19 subjects without OA (54.5±8.6 years; 10 males aged
41.3±9.3; 9 females aged 69.1±14.9). Plasma concentrations of silicon and magnesium (spectrophotometric methods) and
ionized calcium (potentiometric method) were determined.
Results. Silicon in OA patients was significantly increased vs. control. In OA males and OA females, silicon was enhanced vs. the
respective controls, but it was statistically significant only in males. Magnesium in OA patients was not significantly different
from control group. In females, a significant decrease vs. the respective control was observed. No significant differences were
observed in the case of ionized calcium. Positive correlations between silicon and magnesium in healthy control, both in the
whole group and in male and female subgroups, were noted, while no such effect was observed in OA subjects.
Conclusions. The results might suggest some connection between higher OA incidence in women and the depleted
magnesium in the organism. Silicon increase in OA patients, especially in men, may indicate its intense metabolism during
the articular inflammatory process, likely dependent on sex hormones. It remains open whether the plasma Si increase is
the effect or cause of OA.
关键词：osteoarthritis of knee; silicon; calcium; magnesium; males; females
