期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2019
卷号：26
期号：1
页码：1-5
DOI：10.26444/aaem/96331
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. Prostate cancer (PC) is the most commonly diagnosed malignant tumour and the third cause of cancer deaths
among men in Europe. The treatment of early-stage PC is very effective and in many cases allows achievement of a complete
cure, whereas the treatment of metastatic prostate cancer (mPC) is still a huge challenge for clinicians. New therapeutic
strategies for mPC are urgently needded. One of the most promising methods of treatment is anticancer immunotherapy
including the monoclonal antibodies against immune checkpoint inhibitors.
Objectives. To present the potential possibilities of using checkpoint inhibitors blockage in the treatment of mPC, and to
overview the results of recent research on immune checkpoint inhibitors in patients with PC.
State of knowledge. Recent studies suggest that monoclonal antibodies directed against immune checkpoint inhibitors
in combination with traditional therapy may become a breakthrough in the treatment of mPC in the near future.
Conclusions. The immunotherapy using monoclonal antibodies against immune checkpoint inhibitors seems to be a
new opportunity for patients with advanced PC. The key to achieve the maximum anti-tumour response is to choose
the best candidates for this therapy and determine the optimal sequence and combination of drugs. The introduction of
immunotherapy as the standard treatment of patients with advanced PC requires further studies.
