期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2019
卷号：26
期号：1
页码：1-5
DOI：10.26444/aaem/100536
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. In Poland, an increasing number of patients are hospitalized due to liver diseases. One of the common liver
diseases is cirrhosis, which can be caused by alcohol, viral hepatitis, autoimmune processes and metabolic diseases.
Materials and method. The study included 99 patients with alcoholic cirrhosis from the Lublin region of Eastern Poland.
The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The concentrations
of serum kallistatin and chemerin were determined using ELISA kits.
Objective. The aim of the study is to evaluate serum levels of kallistatin and chemerin in patients with different stages of
alcoholic liver cirrhosis.
Results. The highest chemerin level was found in the control group – 182.6±80.4 ng/ml. In other stages of liver cirrhosis, the
following levels were observed: 175.7±62.7 ng/ml in Child-Pugh stage A (Ch-P A), 150.2±59.7 ng/ml in Ch-P B and 110.3±73.6
ng/ml in Ch-P C. Significant differences in chemerin levels between controls and Ch-P C patients (p=0.01), as well as between
the Ch-P A patients and Ch-P C patients (p=0.02), were demonstrated.
The highest kallistatin level was demonstrated in the control group – 8.2±3.5 μg/ml. In other stages of liver cirrhosis, the
following concentrations were found: 7.2±27 μg/ml in Ch-P A, 4.4±2.2 μg/ml in Ch-P B and 3.5±1.9 μg/ml in Ch-P C (Tab. 3).
Statistically significant differences were observed between controls and Ch-P B patients (p<0.001), controls and Ch-P C
patients (p<0.001), Ch-P A and Ch-P B patients (p=0.01), as well as Ch-P A and Ch-P C patients (<0.001).
Conclusions. The levels of chemerin and kallistatin decrease with progression of liver damage during alcoholic liver cirrhosis.
The impairment of its synthetic function leads to reductions in levels of the adipokines studied.
