期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2019
卷号：26
期号：1
页码：1-5
DOI：10.26444/aaem/102293
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Toxocariasis, predominantly caused by Toxocara canis, is a common zoonotic parasitosis
worldwide. Toxocara infection is a cause of vision impairment and blindness. The presented study investigates the frequency
of antibodies against Toxocara among uveitis patients and the epidemiological factors associated with disease.
Materials and method. Fifty-four patients with uveitis and 59 healthy subjects were studied. Anti-Toxocara antibodies
status was determined in all serum samples using enzyme linked immunosorbent assay (ELISA), and seropositive samples
analyzed by Western blot (WB) technique.
Results. The frequency of Toxocara canis infection was found to be significantly higher in uveitis patients, compared to
healthy controls by the use of ELISA test, being 14.8% and 1.7%, respectively. From 8 seropositive samples, 5 (62.5%) patients
exhibited Toxocara immunoglobulin G (IgG) antibodies in response to Western blot, whereas in the control group, none
were detected positive by Western blot. No significant difference was found between pet owners, nor between different
places of residence. The seroprevalence to Toxocara among uveitis patients was significantly related to gender, age and
medical diagnosis. The highest prevalence was found in patients with posterior uveitis (27.8%).
Conclusion. Anti-Toxocara antibody titers are associated with the risk of vision impairment -uveitis. The risk factor associated
with Toxocara exposure identified in this study warrants further investigation.
关键词：toxocariasis; diagnosis; uveitis patients; Toxocara canis; ELISA; Western blot
