标题：Bacteriophages, phage endolysins and antimicrobial peptides – the possibilities for their common use to combat infections and in the design of new drugs
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2019
卷号：26
期号：2
页码：1-7
DOI：10.26444/aaem/105390
出版社：Institute of Agricultural Medicine in Lublin
摘要：The antibiotic resistance in many pathogenic bacteria has become a major clinical problem, therefore, the necessity arises to
search for new therapeutic strategies. The most promising solution lies in bacteriophages, phage endolysins and antimicrobial
peptides. The aim of this study is to review the possibilities for the common use of bacteriophages, phage endolysins and
antimicrobial peptides, both in the form of combined therapies and new strategies for the production of peptide drugs.
Bacteriophages are viruses that specifically infect and destroy pathogenic bacteria by penetration into bacterial cells,
causing metabolism disorders and, consequently, cell lysis. Phage-encoded endolysins are bacteriolytic proteins produced
at the end of the phage lytic cycle that destroy elements of bacterial cell wall and enable the release of phage progeny
from host cells. Antimicrobial peptides (AMPs) constitute an element of the innate immunity of living organisms and are
characterized by the activity against a broad spectrum of bacteria. In the literature, there are only a few reports on the direct
interaction of bacteriophages, phage endolysins and antimicrobial peptides against pathogenic bacteria. In each of them,
a synergistic effect was observed, and Phage-encoded antimicrobial peptides as a specific group of AMPs have were also
discussed. Phage-display technique was also reviewed in terms of its applications to produce and deliver biologically active
peptides. The literature data also suggest that bacteriophages, phage endolysins and antimicrobial peptides can be used
in combined therapy, thus negating many of the limitations resulting from their specificity as a single antimicrobial agent.
