期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2019
卷号：26
期号：2
页码：1-7
DOI：10.26444/aaem/104586
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. In animal models, gestational exposure to inorganic arsenic has been associated with higher corticosterone
concentration and consequent impairment of stress control in offspring. An equivalent association relating cortisol, a
glucocorticoid hormone, in humans has not been previously studied.
Objective. The aim of the study was to explore the association between prenatal inorganic arsenic exposure and salivary
cortisol in infants from Arica, Chile.
Materials and method. A cohort study of 168 mother-child dyads was recruited. In the 2nd trimester of pregnancy, urinary
inorganic arsenic was assessed; 18–24 months after delivery, salivary cortisol was measured in the children. Maternal cortisol,
maternal depression, stress, and socio-economic status were also evaluated.
Results. The adjusted association was estimated with multiple linear regression after evaluating confounding through a
directed acyclic graph. Median urinary inorganic arsenic in pregnant women was 14.1 µg/L (IQR: 10.4–21.7) while salivary
cortisol in the children was 0.17 µg/L (IQR: 0.11–0.38). Among children from the highest income families (> 614 USD/month),
arsenic exposure was associated with salivary cortisol. Children in the third quartile of arsenic exposure had -0.769 units of
the logarithm of salivary cortiso, compared with those in the first quartile (p=0.045).
Conclusions. In this sample, prenatal exposure to arsenic was associated with salivary cortisol (third quartile of inorganic
arsenic), only in infants belonging the highest income strata (>614 USD). More studies are needed to confirm these
preliminary results.
