期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2019
卷号：26
期号：3
页码：1-6
DOI：10.26444/aaem/106765
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. The epidemic of human immunodeficiency virus has had a tremendous effect on the epidemic of tuberculosis.
Together with the spread of HIV, a great increase has been observed in morbidity due to tuberculosis, both in endemic
countries and in those where earlier, as a result of treatment, the frequency of occurrence of tuberculosis had decreased.
In 2018, the WHO data demonstrated that the EECA region was the only region worldwide where the epidemics of HIV was
still rapidly increasing. The EECA region still struggles with a serious epidemic of tuberculosis.
Materials and method. The research method applied was comparative analysis of the results of own study and studies
by other researchers, concerning the effectiveness of tuberculosis prophylaxis in patients with HIV/AIDS when treated with
isoniazid.
Results. In own study, it was found that primary morbidity among patients administered isoniazid significantly decreased
within 5 years. Incidence rates of primary morbidity were significantly lower than among patients who had not received
isoniazid. Relevant studies conducted worldwide, in many cases differed from own study with respect to both the results
and approach to the problem, by country or selection of the type of patients participating in the study. However, in all
studies, isoniazid was generally a safe and well-tolerated drug, without special side-effects.
Conclusions. All studies analyzed concerning the effectiveness of tuberculosis prophylaxis in patients with HIV/AIDS treated
with isoniazid, confirmed the effectiveness of this drug. In the compared studies, applied isoniazid preventive therapy
showed no difference in effectiveness according to its duration. Analyzed studies showed similar effectiveness also with
respect to a decrease in mortality among patients with TB/HIV/AIDS.
