标题：Role of Fruit Waste and Flavanones-Loaded Silica Nanoparticles in Ameliorating Oxidative Stress and Histological Changes in Rat Brain Induced by Acrylamide
期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2018
卷号：9
期号：6
页码：1817-1828
DOI：10.26872/jmes.2018.9.6.202
出版社：University of Mohammed Premier Oujda
摘要：Acrylamide (AA) is a known industrial toxic chemical formed during the heating processof foods contain carbohydrates and proteins. AA produced neurotoxicity characterized byprogressive neuronal degeneration. This study was designed to investigate the effects ofnanoparticles biosynthesized using fruit waste material and two isolated flavanones on AAinducedneuronal damage in Wistar rats. The enzyme activities of oxidative stressbiomarkers included superoxide dismutase (SOD) and catalase were significantlyincreased. Also, the level of malondialdehyde (MDA) increased while the reducedglutathione (GSH) level decreased following AA treatment. AA administered rats showedincreased levels of lipidperoxidative product and total proteincarbonyl content, andhydroperoxide, which were significantly modulated by the supplementation of silicananoparticles (SNs) of hesperitin (Hst) and naringenin (Nrg). The present data showedamelioration with the activities of enzymes antioxidants and levels of reduced glutathione,which were lowered in AA-induced neurotoxicity in rats. Histological observation in rat'sbrain architecture represented the protective role of SNs of Citrus aurantium albedo extract(CAE), Hst-SNs, and Nrg-SNs in AA-induced neuronal damage. This study providesevidence for the neuroprotective effect of the investigated flavanones on AA-inducedneurotoxicity by reducing oxidative stress, up-regulating brain antioxidant status, anddiminished brain damage.
关键词：Acrylamide; GSH; SOD; Catalase; Lipid hydroperoxide; Protein carbonyl;
