摘要:What is already known about this topic? U.S. patients pay 14% of prescription drug costs out of pocket. Limited information exists about whether out-of-pocket costs for human immunodeficiency virus (HIV) medication are associated with treatment adherence. What is added by this report? Analysis of Medical Monitoring Project data found that approximately 14% of persons with HIV infection used prescription drug cost-saving strategies; 7% had cost saving–related nonadherence, which was associated with unmet need for the Ryan White AIDS Drug Assistance Program (ADAP), not having Medicaid, having private insurance, lower HIV medical care engagement, and lower viral suppression. What are the implications for public health practice? Removing barriers to ADAP and Medicaid and reducing private insurance medication costs might decrease cost saving–related nonadherence among persons with HIV infection and improve their health.