出版社：Sociedad Española de Dietética y Ciencias de la Alimentación (SEDCA)
摘要：Cancer is one of the leading causes of morbidity and mortality
worldwide according to the WHO. Strong evidence suggests
that food and nutrition are important in modification of
cancer process. There is increased evidence that specific dietary
patterns or constituents such as n-3 PUFAs, may be associated
with reduced risk of BC. Female athymic nude mice
were fed since weaning to adulthood with a DHA+EPA
(4%w/w) diet or with standard diet during 14-week. At week7,
tumor cell implantation with MDA-MB-231cell line took
place, each mice received 5x106 tumor cells. When tumors
became palpable, maximum length, width, and diameters
were measured twice a week. Incidence of tumor development
was observed in all mice (n=4, 100%) in the control diet
group; instead, the n-3 PUFAs diet group, only two mice developed
tumor (n=2, 50%), and the development time was
longer compared to the control group. These differences were
significant (p < 0.001). This study establish the potential effect
as a preventive measure to BC. This evidence is consentient
with epidemiological data about high n-3 PUFAs diet patterns
in some populations may lower risk of BC, highlighting
the importance of these components in our diet since childhood
to promote the preventive effect. Being thus necessary,
setting up recommendations for n-3 PUFAs supplementation
from fish oil or, for a minimal dietary fatty fish intake/week, in
order to attempt modulate carcinogenesis in populations at
high risk, particularly those with a high prevalence of obesity.
