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  • 标题:Engineered Bacteriophages for Practical Applications
  • 本地全文:下载
  • 作者:Javier Pizarro-Bauerle ; Hiroki Ando
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2020
  • 卷号:43
  • 期号:2
  • 页码:240-249
  • DOI:10.1248/bpb.b19-00914
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The diversity of advanced genetic engineering techniques that have become available in recent years has enabled a more precise manipulation of genes and genomes. Among these, bacteriophage genomes stand out as an interesting target due to their dependence on a host for replication, which previously complicated their manipulation, and due as well to the many possible fields in which they can be used. In this review, we highlight recent applications for which genetically modified bacteriophages are being employed: as phage therapy in medicine, animal industries and agricultural settings; as a source of new antimicrobials; as biosensors for research, health and environmental purposes; and as genetic engineering tools themselves..
  • 关键词:bacteriophage;synthetic biology;phage therapy;biosensor;directed;evolution
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