期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2019
卷号：65
期号：6
页码：541-544
DOI：10.3177/jnsv.65.541
出版社：Center for Academic Publications Japan
摘要：The absorption of vitamin B 12 is a complex process involving gastric acid and intrinsic factor as the indispensable components. In this study, we have investigated the effects of the administration site in enteral feeding on vitamin B 12 status in subjects with severe motor and intellectual disabilities (SMID). This is a cross-sectional study conducted from January to June 2016. Blood concentrations of vitamin B 12 , folate, vitamin B 6 , and homocysteine (Hcy) were measured in a total of 82 subjects (38 men, 44 women). Also, nutrients intake was assessed. Subjects with enteral feeding (EF) had significantly higher intakes of vitamin B 12 , folate, and vitamin B 6 than those with oral ingestion (OI). Serum folate and vitamin B 6 concentrations in subjects with EF were significantly higher than those with OI. Among the EF subjects, serum vitamin B 12 concentration was significantly higher in those fed with gastric tube than those fed with jejunal tube in spite of similar vitamin B 12 intakes. No significant difference was observed between the two groups regarding the circulating concentrations of folate, vitamin B 6 , or Hcy. Although each administration route has its own benefit, gastric tube is advantageous in the absorption of vitamin B 12 ..
关键词：vitamin B12;enteral feeding;stomach;jejunum;severe motor intellectual disabilities
