出版社：International Medical Journal Management and Indexing System
摘要：The plant Guiera senegalensis is commonly used in improving lactation in the North
Western part of Nigeria. Aqueous extract of the plant Guiera senegalensis known as
‘Sabara’ in Hausa language, was investigated for possible milk production effect in
Wistar rats. Six groups of five lactating rats each were dosed. Group A was used as the
negative control and Group F which received 0.1 IU of oxytocin was used as positive
control. The other four groups (B, C, D, and E) received 50mg, 100mg, 200mg, and
400mg of the extract respectively. Group C showed the highest response with statistical
significance at P<0.05 when compared to groups A, D, E, and the positive control (group
F). Isolated tissue experiment using the Ugo Basile micro dynamometer showed that the
extract was able to stimulate uterine contractions at a dose of 0.3 mg/ml, but no
contractions were recorded at 0.6 mg/ml. There were no contractions seen when the
extract was tested on intestinal tissue. Acetyl choline was used as a positive control in
both the uterine and intestinal tissue. The effect of acetyl choline was compared to the
effect of the extract on both tissues. The experiment showed that higher concentrations
of the plant extract were not capable of inducing smooth muscle contractions. The lack
of smooth muscle contractions at higher doses was similar to what was observed in the
milk production activity that was related to pup weight gain. Thus, milk production did
not increase significantly with higher doses. In conclusion, the water extract of Guiera
senegalensis has a positive galactagogue effect.
