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  • 标题:Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients
  • 本地全文:下载
  • 作者:Paul Thomas Brinkkoetter ; Franziska Grundmann ; Panteha Jazayeri Ghassabeh
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2019
  • 卷号:9
  • 期号:1
  • 页码:1-10
  • DOI:10.1038/s41598-019-49054-8
  • 出版社:Springer Nature
  • 摘要:This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age ≥70 years and serum sodium 0.2) in the overall analysis for ΔADL and ΔMMSE and moderate (i.e., >0.5) for ΔMMSE in the euvolemic subgroup. Beneficial effects on ΔADL and ΔMMSE were only observed in the subgroup of patients in which [Na + ] was raised by >5 mEq/L and multivariable linear regression analysis confirmed [Na + ] increase to be an independent predictor of MMSE improvement. Resolution of hyponatremia has a beneficial impact on the geriatric patients' overall functional status, in particular in euvolemic cases.
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