摘要：Mixed-effects models were used to evaluate the global zoning concept using residue data from a comprehensive
database of supervised field trials performed in various countries and regions on a variety of
pesticide–crop combinations. No statistically significant systematic differences in pesticide residues were
found between zones among the pesticide uses examined. In addition, we conducted a simulation to assess
the impact of using regional versus global datasets for calculating maximum residue limits (MRLs). The
conclusion of this assessment supports the concept of exchangeability of pesticide residue values across
geographic regions and opens the possibility of improving harmonization of pesticide regulatory standards
by establishing more globally aligned MRLs. Supplemental material for this article is available online.
关键词：Codex ; International trade ; JMPR ; Maximum residue limits ; Mixed-effects models
