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  • 标题:Optical separation and controllable delivery of cells from particle and cell mixture
  • 本地全文:下载
  • 作者:Yuchao Li ; Hongbao Xin ; Chang Cheng
  • 期刊名称:Nanophotonics
  • 印刷版ISSN:2192-8606
  • 电子版ISSN:2192-8614
  • 出版年度:2015
  • 卷号:4
  • 期号:3
  • 页码:353-360
  • DOI:10.1515/nanoph-2015-0008
  • 出版社:Walter de Gruyter GmbH
  • 摘要:Cell separation and delivery have recently gained significant attention in biological and biochemical studies. In thiswork, an optical method for separation and controllable delivery of cells by using an abruptly tapered fiber probe is reported. By launching a laser beam at the wavelength of 980 nm into the fiber, a mixture of cells with sizes of ~5 and ~3 μm and poly(methyl methacrylate) particles with size of 5 μm are separated into three chains along the direction of propagation of light. The cell and particle chains are delivered in three dimensions over 600 μm distance. Experimental results are interpreted by numerical simulations. Optical forces and forward migration velocities of different particles and cells are calculated and discussed.
  • 关键词:optical manipulation ; optical separation ; cell delivery ; tapered optical fiber
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