摘要：Background: The traditional medicine ipe is thought to have various pharmacological actions
including anticancer and anti-inflammatory activities.However,there is little scientific evidence
to demonstrate the organ-protective effects of ipe.The prevention of nitric oxide (NO)production
in inflamed livers by inducible NO synthase (iNOS) is an indicator of liver protection.We
examined proinflammatory cytokine-stimulated hepatocytes as a simple“in vitro liver injury
model”to determine ipe's liver-protective effects of ipe and clarify its mechanisms. This study
aims to examine whether ipe influences iNOS induction and NO production，and if so，the
mechanisms involved in its action.
关键词：ipe;induciblenitric oxide synthase,liver injury,primary cultured hepatocytes,nuclearfactor-KB,the type I interleukin-1 receptor,iNOS antisense transcript
