摘要：The function annotation process in computational biology has increasingly shifted from the traditional characterization of individual biochemical roles of protein molecules to the system-wide detection of entire metabolic pathways and genomic structures. The so-called genome-aware methods broaden misannotation inconsistencies in genome sequences beyond protein function assignments, encompassing phylogenetic anomalies and artifactual genomic regions. We outline three categories of error propagation in databases by providing striking examples – at various levels of appreciation by the community from traditional to emerging, thus raising awareness for future solutions.
关键词：Genome-wide annotation;Genome-aware methods;Protein function prediction;Next-generation sequencing;Mis-annotation modeling;Error propagation;Genome structure;Genome evolution
