摘要：Background: Both extreme heat and air pollution exposure during pregnancy have been associated with preterm birth; however, their combined effects are unclear. Objectives: Our goal was to estimate the independent and joint effects of heatwaves and fine particulate matter [PM 0 ) for less extreme heatwaves (i.e., shorter or with relatively low temperature thresholds) but were less than additive ( RERIs < 0 ) for more intense heatwaves. Conclusions: Our research strengthens the evidence that exposure to heatwaves during the final gestational week can independently trigger preterm birth. Moderate heatwaves may also act synergistically with PM 2.5 exposure to increase risk of preterm birth, which adds new evidence to the current understanding of combined effects of air pollution and meteorological variables on adverse birth outcomes.
