摘要:A combination of geological evidence (in the form of hydrothermal vein systems in exhumed fault systems) and geophysical information around active faults supports the localized invasion of near-lithostatically overpressured aqueous fluids into lower portions of the crustal seismogenic zone which commonly extends to depths between 10 and 20 km. This is especially the case for compressional–transpressional tectonic regimes which, beside leading to crustal thickening and dewatering through prograde metamorphism, are also better at containing overpressure and are ‘load-strengthening’ (mean stress rising with increasing shear stress), the most extreme examples being associated with areas undergoing active compressional inversion where existing faults are poorly oriented for reactivation. In these circumstances, ‘fault-valve’ action from ascending overpressured fluids is likely to be widespread with fault failure dual - driven by a combination of rising fluid pressure in the lower seismogenic zone lowering fault frictional strength, as well as rising shear stress. Localized fluid overpressuring nucleates ruptures at particular sites, but ruptures on large existing faults may extend well beyond the regions of intense overpressure. Postfailure, enhanced fracture along fault rupture zones promotes fluid discharge through the aftershock period, increasing fault frictional strength before hydrothermal sealing occurs and overpressures begin to reaccumulate. The association of rupture nucleation sites with local concentrations of fluid overpressure is consistent with selective invasion of overpressured fluid into the roots of major fault zones and with observed non-uniform spacing of major hydrothermal vein systems along exhumed brittle–ductile shear zones. A range of seismological observations in compressional–transpressional settings are compatible with this hypothesis. There is a tendency for large crustal earthquakes to be associated with extensive ( L ~ 100–200 km) low-velocity zones in the lower seismogenic crust, with more local Vp/Vs anomalies ( L ~ 10–30 km) associated with rupture nucleation sites. In some instances, these low-velocity zones also exhibit high electrical conductivity. Systematic, rigorous evaluation is needed to test how widespread these associations are in different tectonic settings, and to see whether they exhibit time-dependent behaviour before and after major earthquake ruptures.