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  • 标题:Development of Hydrophilic Polyacrylamide Gel-Based Condensing Reagents Comprised of Chlorotriazine
  • 本地全文:下载
  • 作者:Kohei Yamada ; Shota Hirozawa ; Junqing Xia
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2020
  • 卷号:68
  • 期号:6
  • 页码:534-537
  • DOI:10.1248/cpb.c20-00074
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Hydrophilic polyacrylamide gel-based triazine-type condensing reagents, PAG-Trz-Cl, have been developed. PAG-Trz-Cls were synthesized using a chlorotriazine with an acrylamide moiety, acrylamide, and N , N ′-methylenebisacrylamide via both precipitation and solution polymerization. Because PAG-Trz-Cls adequately swell in aqueous media, the amidation between polar carboxylic acids and amines afforded the corresponding amides in good yields.
  • 关键词:aqueous solvent;condensation;polyacrylamide;triazine
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