摘要:The article examines the clusters with research centers/institutions as a core. The cluster model has been developed on the basis of the modified theory of “growth poles”, taking into account the main provisions of the theory of “structures with direct and indirect relations”. Based on a survey among representatives of science, business and government, calculated are the values of indicators of economic expectations of return on invested capital in basic and applied research. An economic and mathematical model has been developed and the dependence between GDP volumes and the level of research funding have been established. It is proved that in the conditions of the Ukrainian economy, research centers/institutions should be the center of the cluster and the start component of regional economic development.