摘要：The metabolic syndrome is also called insulin resistance syndrome.1 This term was used for the first time in 1922 to describe the few cases of patients with diabetes who required increasing doses of insulin to maintain normoglycemia. Most of these patients developed insulin resistance secondary to the production of antibodies directed against exogenous insulin, which was not sufficiently purified at the time, and what is more, it was obtained from other animal species.2 Insulin resistance is currently defined as the body's insufficient response to specific insulin levels. The clinical spectrum of insulin resistance is broad and includes both diabetic patients who require insulin therapy and experience hyperglycemia despite high doses of exogenous insulin, as well as patients with severe insulin resistance who maintain almost normal blood glucose levels due to significantly higher endogenous insulin secretion.
关键词：The metabolic syndrome is also called insulin resistance syndrome.1 This term was used for the first time in 1922 to describe the few cases of patients with diabetes who required increasing doses of insulin to maintain normoglycemia. Most of these patients developed insulin resistance secondary to the production of antibodies directed against exogenous insulin, which was not sufficiently purified at the time, and what is more, it was obtained from other animal species.2 Insulin resistance is currently defined as the body's insufficient response to specific insulin levels. The clinical spectrum of insulin resistance is broad and includes both diabetic patients who require insulin therapy and experience hyperglycemia despite high doses of exogenous insulin, as well as patients with severe insulin resistance who maintain almost normal blood glucose levels due to significantly higher endogenous insulin secretion.
