摘要：Background: Diabetes Mellitus (DM) is a major non-communicable health problem that has effects on glycemic
status. Hyperglycemia that is an inherent finding of diabetes causes platelet dysfunction. Oral omega-3 fatty acid
supplementation may improve glycemic status in diabetic patient and reduce micro and macrovascular
complications.
Objective: To observe the effect of supplementation of omega-3 fatty acid on Mean Platelet Volume (MPV) and
Platelet count in type 2 DM.
Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total
numbers of 52 diagnosed type 2 diabetic patients of both sexes were selected within age 40 to 50 years. Among
them, 27 type 2 diabetic patients with supplementation of omega 3 fatty acid (2g/day) for 12 weeks were
considered as study group and another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid
were considered as control group. The study subjects were selected from Outpatient Department of
Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city. MPV and
platelet count were measured by hematology analyzer. The study parameters were measured at base line and
after 12 weeks of study period in both groups.
Results: In this study MPV and platelet count levels were significantly lower (p<.001) in diabetic patients after
supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks,
MPV and platelet count were significantly lower (p<.001) in diabetic patients after supplementation with
omega-3 fatty acid in comparison to control group. In control group, MPV and Platelet count were almost
similar both at baseline and after 3 months of follow-up.
Conclusion: After analyzing the results of the study it can be concluded that omega-3 fatty acid may improve
MPV and Platelet count levels in type 2 diabetic patients and may be helpful to minimize the complications of
type-2 DM.
关键词：DM; MPV; Platelet count and Omega-3 fatty acid
