期刊名称：Pakistan Journal of Analytical & Environmental Chemistry
印刷版ISSN：1996-918X
电子版ISSN：2221-5255
出版年度：2004
卷号：5
期号：2
页码：91-94
语种：English
出版社：National Centre of Excellence in Analytical Chemsitry
摘要：A simple,accurate and low cost spectrophotometric method for the determination of secnidazole in raw and pharmaceutical dosage forms has been developed. The proposed method is based on the reduction of the nitro group of the drug to amino group in the presence of Zinc dust and HCl. This reduced product then reacts immediately with p-benzoquinone and develops color,which has maximum absorbance at 532 nm. The calibration graph is linear over the concentration range of 12.5-160 µgml-1 with molar absorption coefficient of 1.5 × 103 Lmole-1 cm-1 .The common excipients and additives do not interfere in the determination. The proposed method is applied successfully to commercially available tablets and results are statistically compared with those obtained by reference method..
